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Prostate Cancer Discoveries Digest

Welcome to your monthly summary of the notable research studies and developments that help provide greater insight into prostate cancer causes, treatments, outcomes, and survivorship.

Prostate Cancer Discoveries Digest

Welcome to the March 2025 edition of ZERO’s Prostate Cancer Discoveries Digest. The latest information on treatment, diagnostics, survivorship, and more has been pulled from the headlines and delivered to your inbox.

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ZERO Prostate Cancer does not endorse any particular article or finding that may be featured.

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Treatment

Many Men with Metastatic Prostate Cancer Are Not Getting the Recommended Treatments, Study Finds

Nearly 70% of doctors who care for prostate cancer patients report they do not use combination therapy upfront for hormone-sensitive prostate cancer, which is the current recommendation.

» Full Article from the National Cancer Institute

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Survivorship

Healthy Lifestyle Choices May Reduce Risk of Death in Prostate Cancer Patients

In this new study, healthy lifestyle and dietary choices were associated with a reduction in mortality from any cause but not associated with prostate cancer-specific survival. Differences also existed between racial and ethnic groups.

» Full Article from Cancer Therapy Advisor

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Treatment

ATAD2 Drives Prostate Cancer Progression to Metastasis

ATAD2 is a genetic driver linked to prostate cancer progression and metastases. Data in mouse models and human cohorts leads researchers to believe a more functional role in inhibiting this driver in patients is on the horizon, leading to a new therapeutic agent.

» Full Article from the American Association for Cancer Research

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Diagnostics

Positive PSMA Scan Even at Low PSA Prognostic After Prostate Cancer Surgery

More than one-third of patients with PSA levels less than 0.5 ng/mL after primary radical prostatectomy for prostate cancer have PSMA activity suspicious for recurrence, a new study finds.

» Full Article from Renal+Urology News

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Treatment

Impact of Physicians' Awareness of PSADT on Treatment Decisions in High-Risk BCR Prostate Cancer

Results from this study indicate that most physicians don’t know their patient’s PSA doubling time, limiting the opportunity for these patients to receive guideline-directed prostate cancer treatment.

» Full Article from the Journal of Clinical Oncology

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Diagnostics

Who Needs Additional Imaging for Prostate Cancer Staging?

Results from a study presented at the Advanced Prostate Cancer Consensus Conference (APCCC) helped identify which patients might need additional imaging for prostate cancer staging.

» Full Article from UroToday

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Treatment

Enrollment Goal Met in Trial of Vanquish Device for Localized Prostate Cancer

A phase 2 clinical trial exploring a promising new technology that uses water vapor to treat prostate cancer precisely has fully enrolled. The company expects to file for a 501(k) application in July 2025.

» Full Article from Urology Times

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Treatment

Active Surveillance Follow-Up for Prostate Cancer: From Guidelines to Real-World Clinical Practice

A recent study on active surveillance (AS) explored the guidelines compared to real-world, everyday practice. The data shows that only 11% of patients adhere to published guidelines, indicating the need to balance clinical practice with what patients are willing to tolerate.

» Full Article from UroToday

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Screening

Trends in Prostate Cancer Incidence and Mortality Rates

A study published in JAMA Network Open examined trends of prostate cancer incidence and mortality in California, concluding that with the increase in the incidence rate of distant-stage prostate cancer, more effective prostate cancer screening strategies are critically needed.

» Full Article from JAMA Network

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ZERO Prostate Cancer provides this informational roundup as a resource; it is not intended to replace medical professionals' or your healthcare team's recommendations. Consult your healthcare team if you have questions about your specific treatment plan.

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