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Prostate Cancer Discoveries Digest

Welcome to your monthly summary of the notable research studies and developments that help provide greater insight into prostate cancer causes, treatments, outcomes, and survivorship.

Prostate Cancer Discoveries Digest

Happy New Year!

Welcome to the January 2025 edition of ZERO’s Prostate Cancer Discoveries Digest! The latest information on treatment, diagnostics, survivorship, and more has been pulled from the headlines and delivered to your inbox.

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ZERO Prostate Cancer does not endorse any particular article or finding that may be featured.

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Treatment

PSMA-PET/CT Findings in Patients With High-Risk Biochemically Recurrent Prostate Cancer With No Metastatic Disease by Conventional Imaging

Findings from a new study published in JAMA Network Open further support the use of PSMA-PET imaging for patient selection in clinical and trial interventions and found that many cases of high-risk nonmetastatic hormone-sensitive prostate cancer may be more advanced than previously thought.

» Full Article from JAMA Network

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Health Equity

Study Identifies Genes Linked to High Prostate Cancer Mortality Rates

Researchers shed light on the genes that could be linked to the high mortality rates of prostate cancer among men of African descent.

» Full Article from Nature Africa

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Diagnostics

Rates of PSMA PET Staging and Positivity in Newly Diagnosed Prostate Cancer in a National Health Care System

PSMA PET staging for newly diagnosed prostate cancer increased rapidly in the Veterans Health Administration. Positivity rates were less than 10% in this large intermediate-risk cohort. These data confirm the utility of PSMA PET staging in high-risk disease and suggest that additional study is needed to refine patient selection in intermediate-risk disease.

» Full Article from the National Library of Medicine

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Survivorship

Grading the Evidence for Physical Activity and Any Outcome in Cancer Survivors: An Umbrella Review of 740 Meta-Analytic Associations

A new study provides strong evidence for the positive association of physical activity with cardiovascular fitness, quality of life, and improving fatigue. The evidence supports the introduction of targeted exercise prescription in oncology care.

» Full Article from UroToday

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Survivorship

Knowledge and Worry Following Review of Standard vs Patient-Centered Pathology Reports

Using a newly designed, patient-centered pathology report (PCRP), researchers found that the new report resulted in lower worry, a higher degree of understanding, and increased proper identification of disease grade compared to the standard VA pathology report.

» Full Article at JAMA Network

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Risk

Recent Patterns and Trends in Global Prostate Cancer Incidence and Mortality: An Update

Researchers examined data over a 5-year period and noted incidence rates increased in 11 of the 50 countries in the study, and mortality rates increased in 9 of 59 countries, mostly located in Africa, Asia, Latin America, the Caribbean, and Central and Eastern Europe. These findings reinforce the need for coordinated and concerted efforts to improve early detection and treatment services in low- and middle-income countries to reduce the undue burden of the disease.

» Full Article from European Urology

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Survivorship

High Omega-3, Low Omega-6 Diet May Slow Prostate Cancer Progression

Data from a phase 2 trial showed that a high omega-3, low omega-6 diet supplemented with fish oil capsules significantly reduced the proliferation of Ki-67, a biomarker for prostate cancer progression, metastasis, and death, in patients with prostate cancer who are on active surveillance.

» Full Article from Urology Times

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ZERO Prostate Cancer provides this informational roundup as a resource; it is not intended to take the place of medical professionals or your healthcare team's recommendations. Consult your healthcare team if you have questions about your specific treatment plan.

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