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Newly Diagnosed

You or your loved one has just been diagnosed with prostate cancer. You may be experiencing a number of feelings: disbelief, fear, anger, anxiety, and depression. The good news is that there are many treatment options and support resources that can help you or your loved one lead a normal, healthy life. This section provides information on diagnosis of prostate cancer, staging of prostate cancer, what to expect after an initial diagnosis of prostate cancer, risk assessment, Gleason Grades, and questions to ask the doctor as you or your loved one enter treatment and during recovery, and where to find support.

You may also want to check out:
10 Tips for Responding to Prostate Cancer Diagnosis
Glossary of terms
Educational materials


Two tests are used to help detect prostate cancer—the digital rectal exam and a blood test that measures a protein called prostate specific antigen or PSA. There is no normal PSA level but the higher it is the greater the odds that cancer is present. Prostate cancer may also be present when the PSA is increasing. If any abnormalities are detected in the prostate during the DRE, or if PSA levels are above a certain level, the doctor may recommend further testing. It is recommended that the PSA test take place before the DRE, as the DRE can potentially affect PSA scores.

  • Urine test – Urine is analyzed for abnormalities that may indicate a problem other than prostate cancer, such as bacterial infection, or to rule out conditions that may cause the same signs and symptoms of prostate cancer, such as prostatitis (inflammation of the prostate) and benign prostatic hyperplasia (enlarged prostate).
  • Transrectal ultrasound – This procedure uses sound waves to visualize the prostate gland and detect any abnormalities. It can measure prostate gland volume, identify appropriate sites for biopsy or be used to guide the biopsy needle for random biopsies.
  • Transrectal power Doppler ultrasound (also known as Doppler scan) – This procedure is similar to the transrectal ultrasound, but a Doppler shift measures blood flow and resistance levels in veins and arteries. The rapid flow of blood through tiny blood vessels that are characteristic of tumors can be observed. Currently, this test is not used very often.
  • Multi-parametric MRI – This test obtains several images that are gaining popularity for determining if prostate cancer is present. A standardized method for evaluating each scan called PI-RADS (Prostate Imaging and Reporting Archiving Data System) is being used to decide which men should undergo a biopsy. It assigns a rating from 1-5, and values of 3-5 are indications for a biopsy. Some men may avoid a biopsy if the MRI does not show any suspicious areas. Its exact role is still evolving.

Ultrasounds help in diagnosing, staging, and treatment plans by measuring prostate gland volume, recognizing varied patterns of cancer, and identifying appropriate sites for biopsy. Ultrasonography alone, however, cannot detect all cancers.

Prostate Biopsy – If these test results indicate the presence of prostate cancer, the next step is a prostate biopsy to collect small tissue samples from the prostate for analysis by a pathologist. Biopsy results are usually obtainable within 48 hours.

Two kinds of biopsies are generally performed – transrectal or transperineal. Transrectal is the most common. An enema and an oral antibiotic are often given prior to the biopsy. Injecting a local anesthetic into the tissue around the prostate can greatly reduce pain and discomfort and should be used on all patients. ultrasound-guided biopsy, an ultrasound probe into the rectum.

The ultrasound images show the contour of the prostate and allow the doctor to direct the biopsy needle to specific locations in the prostate. From outside the rectum wall, a handheld device with a spring-loaded, slender needle is positioned and inserted into the abnormal areas to collect tissue samples. If no abnormal areas are detected, 10-12 random tissue samples are collected from different areas of the prostate.

However, MRI is being increasingly being used to guide the placement of the needle into a suspicious area. If none is seen, then random biopsies may be avoided thereby reducing the chances of finding a non-life threatening cancer that is often found when random biopsies are performed. The transperineal procedure is the same as the transrectal procedure, only the needle is inserted through the skin between the rectum and scrotum (perineum). This method is used when access through the rectum wall is not possible.

The transperineal procedure is the same as the transrectal procedure, only the needle is inserted through the skin between the rectum and scrotum (perineum). This method is used when access through the rectum wall is not possible.


If cancer is detected, your doctor may order additional tests to determine if the cancer has spread to other parts of the body. The decision is partly based on the PSA level and the findings on the prostate biopsy. This information is important for deciding which treatment is most appropriate.

  • Bone scan. Detects whether the cancer has spread to the bones. 
  • Computerized tomography (CT) scan. Identifies general signs of disease, such as enlarged lymph nodes* or organ abnormalities that may be related to prostate cancer. 
  • Magnetic resonance imaging (MRI). Detects spread of cancer to lymph nodes or tissues near the prostate.  
  • Lymph node biopsy. Determines whether the cancer has spread to the lymph nodes.
    *Lymph nodes are small glands located in many parts of the body that help defend against harmful foreign particles. Lymph nodes in the pelvic region are usually the first place to which cancer spreads outside the prostate.
  • Pet Scan – The PET scan is being used increasingly in place of the bone scan to detect cancer in the bones because it is more sensitive.


Staging of prostate cancer is a necessary step to determine the extent of the disease and select the best treatment strategy. A pathologist will look at the tissue that was taken during the prostate biopsy and will determine

  1. The size of the cancer area (percent of biopsy with cancer)
  2. The type of cancer cells

The pathologist will assign a Gleason score based on how the cancer looks under a microscope. Cancer cells are assigned a Gleason grade from 1 to 5. The score of the two most common types of cells are added together to give the Gleason score. In general, the lower the score, the better the prognosis. The most common score is 6. Gleason scores of 8-10 are the most dangerous.

Most of the information listed above will appear on the biopsy report. The report often will describe the length of cancer in each biopsy sample and the percentage of cancer on each core.

After all of the necessary tests are run and the results are available, your doctor will determine the stage of prostate cancer.

Stage III cancer

Stage III cancer is no longer confined to the prostate gland but has not yet spread (metastasized) to tissues outside the pelvic area. T3 tumors may have spread to the nearby seminal vesicles. T4 tumors are slightly more spread out and may have invaded other nearby tissues within the pelvic area including the bladder or pelvic wall.

Stage IV cancer

Stage IV cancer is detected in tissues far from the prostate, including the lymph nodes (N+) or more distant tissues, such as bone (M+).

Once the doctor has determined the stage of the prostate cancer, the doctor will work with you to select the best treatment option.

Risk Assessment

After a prostate cancer diagnosis and staging, you should familiarize yourself with the available risk assessment tools to help understand your risk of disease recurrence and progression.

What is risk assessment?

Prostate cancer can either present as a slow growing tumor causing minimal harm or a more aggressive type, which spreads quickly. Risk assessment is the critical step of determining the nature of each patient’s disease. Physicians look at clinical and pathology features (PSA, Gleason score, clinical stage, etc) to determine which patients may have aggressive forms of prostate cancer, and which patients do not.

Risk assessment using clinical and pathologic information:

  • American Urology Association (AUA) groups (D’Amico classification): Patients with non-metastatic disease are placed into risk categories based on clinical and pathologic features. The three groups are low (PSA <10 ng/mL, Gleason score 4-6, clinical stage T1-T2a), intermediate (PSA 10-20 ng/mL, Gleason score 7, clinical stage T2b-T2c), and high risk (PSA >20 ng/mL, Gleason score 8-10, clinical stage T3a).
  • Partin Tables: predict the likelihood of the patient's cancer being organ-confined after surgery (i.e. pathologic stage) or having spread to the lymph nodes or seminal vesicles
  • Nomograms: paper-based or online calculator methods that incorporate clinical and pathological information to provide risk assessment

Newly diagnosed men become very familiar with their individual PSA and biopsy Gleason scores. Over the last several decades, annual PSA screening has helped identify more men earlier in the disease process. As a result, many patients present with a narrow Gleason score range (Gleason 6 or 7) and low PSA values which compress the results of existing risk assessment and prognostic tools, making them less useful for individual patients. New personalized methods of risk assessment using molecular biomarker analysis are available to assess progression risk. However, their clinical utility is still evolving.

Risk assessment incorporating molecular analysis as well as clinical and pathologic information:

Patients should learn as much as possible about their disease prior to treatment selection. Risk assessment and disease prognosis tools assist in making informed treatment decisions.

Gleason Grades

  • Tissue extracted during the biopsy is examined under microscope by pathologist to assign subjective score that’s the sum of two Gleason grades from 3 to 6.
  • Cell formations are graded on a scale of 1 to 5 (Subjective evaluation)
  • Grade 1 and 2: cell formation is normal and therefore not factored into the Gleason score

Cell formations are graded on a scale of 3 to 5

  • Grade 5: cancer cells appear as sheets; high-grade cancer/aggressive
  • Grade 4: cancer cells appear poorly differentiated (irregular shapes and combinations)
  • Grade 3: cancer cells appear moderately differentiated

    • Gleason score is one number from 6 to 10 that’s the sum of the primary grade and secondary grade
    • First number (primary grade) is most common Gleason score cell pattern found in all tissue samples
    • Second number (secondary grade) is second most common Gleason score cell pattern
    • Therefore a Gleason score of 7 can reflect a different state of prostate cancer depending upon the order of the numbers adding up to 7: 3 + 4 = 7 or 4 + 3 = 7
    • Consider getting a second opinion on biopsy tissue analysis and Gleason score

New Prostate Cancer Grading System

  • Gleason scores of 2 to 5 are no longer assigned
  • Therefore the lowest Gleason score is a 6
  • Rather than 6 being in the middle of scale of 2 to 10, it’s actually the lowest score on scale of 6 to 10
  • Logical assumption of Gleason score of 6 being in the middle can lead to patients expecting that treatment is necessary

New 5 Grade Group System

  • Grade Group 1 (Gleason score ≤ 6) Only individual discrete well-formed glands
  • Grade Group 2 (Gleason score 3+4=7) Predominantly well-formed with lesser component of poorly-formed glands
  • Grade Group 3 (Gleason score 4+3=7) Predominantly poorly-formed glands with lesser component of well-formed glands
  • Grade Group 4 (Gleason score 8) Only poorly-formed/fused glands
  • Grade Group 5 (Gleason score 9 to 10) Lacks gland

What to Expect

Learning more about prostate cancer and the available treatments is the first step towards improving your or your loved one’s outlook and relieving some of the anxiety and stress caused by diagnosis.

  • Always get a second opinion, which may include a physician with a different specialty.
  • Research prostate cancer and treatment options

  • Jot down questions for your doctor
  • Ask about your doctor’s experience in treating prostate cancer
  • Bring along your companion, a family member, or a friend for support and an objective observer who can help translate what occurred in the doctor’s office

Once you or your loved one are diagnosed, your doctor will want to run tests and may need to ask you to have one or two imaging tests such as a bone scan or a computed tomogram (CT) or magnetic resonance image (MRI) to determine the extent of the disease. Depending on the stage of the cancer, the doctor will discuss treatment options.

Certain treatments for prostate cancer are associated with side effects that can have a profound effect on one’s lifestyle. The important thing to remember as a patient is to keep a diagnosis of prostate cancer and the side effects of treatment from interfering with your life or your emotional health. 

  • Try to stick to your normal routine
  • Eat a heart healthy diet and enough calories to support your ideal weight
  • Get plenty of rest
  • Pursue activities that are purposeful and meaningful – go back to work, play with your children or grandchildren
  • Do things you enjoy – take a trip, go golfing
  • Exercise regularly – it improves your physical and emotional sense of well-being
  • Anticipate changes in your lifestyle and find ways to accommodate them

    • Incontinence (loss of urinary control) – sit at the back of the movie theater, sit on the aisle in an airplane
    • Erectile dysfunction – seek out sexual contact and reestablish intimacy
  • Seek out support from your family and friends

Join a support group for prostate cancer patients

Questions For Your Doctor

The following is a list of questions to ask your doctor if you have been diagnosed with prostate cancer. It may be worthwhile to audio record your conversation with your doctor so that you can review his answers to each question and be able to make informed decisions about your treatment options.

After Diagnosis

  • What additional tests will I need?
  • What is the stage of my cancer?
  • Has my cancer spread and if so, how far?
  • What are the treatment options for this stage of cancer?
  • What are the benefits and risks of the type of therapy you are recommending?
  • What are the odds my cancer will return with this therapy and how does it compare to the other treatments available?
  • What side effects are associated with the type of therapy that you are recommending and how often do they occur in your patients?
  • What can I do to improve the success of my therapy?
  • Are there other treatment options?
  • Should I consider participating in a clinical trial?
  • Can you refer me/us to a colleague who is not associated with this institution for a second opinion?
  • Where can I find out more about my or my loved one’s treatment options?
  • Where can I find advice about coping with the emotional impact of prostate cancer diagnosis and therapy?
  • Are there any cancer support centers nearby?


  • How many of these operations have you performed?
  • What level of success have you had following surgery in preserving erectile function and/or continence in patients similar to me in age and health?
  • What can I expect following the surgery in terms of recovery time and short- and long-term side effects?
  • What kind of follow-up can I expect after surgery?

Radiation Therapy

  • What type of radiation therapy will you be using and why?
  • What level of success have you had in preserving erectile function in your patients following this type of radiation therapy?
  • What can I expect following radiation therapy in terms of recovery time and short- and long-term side effects?
  • What kind of follow-up is needed after radiation therapy?
  • Will I also receive androgen deprivation therapy and, if so, for how long?

Hormone Therapy

  • What type of hormone therapy do you recommend and why?
  • What side-effects can I expect from this type of therapy?
  • How long will I need to receive hormone therapy?
  • What are my options in terms of continuous versus intermittent hormone therapy?

Read a list of questions for urologists, radiation oncologists and medical oncologists, as compiled by an experienced prostate cancer patient

View list of questions created by Prostate Problems mailing list participants

You can also post questions for physicians and join discussions on specific topics about prostate cancer on the Physician-to-Patient (P2P) bulletin board located in the Online Communities: Prostate Pointers section of this Web site.

Finding Support

This section lists only some of the many support resources available that can help you learn more about prostate cancer and its treatment, and that can connect you to medical experts, other patients, caregivers, and families. For a more comprehensive list, please visit the Helpful Resources section.

While the Internet has become a valuable source of information and support for those dealing with prostate cancer, Us TOO recommends that you verify all information you obtain from the Internet with your doctor.

  • Your doctor is a good resource who can give you information about prostate health and cancer, and who can direct to you other resources of support.
  • Find a urologist. Also visit AUA’s Urology Health website for additional excellent information on adult conditions of the prostate.
  • Find a medical oncologist in your area by consulting the American Society of Clinical Oncology (ASCO).
  • Find a local Us TOO support group chapter. The Us TOO mission is based on the Chinese proverb, “To know the road ahead, ask those coming back.” Talk to other men who have been diagnosed and treated, and/or speak to the wives and companions who are supporting their partners through their diagnosis, treatment and life after cancer.
  • There are several national and international groups in addition to Us TOO that promote education about prostate cancer and its treatment, provide support, and act as advocates for prostate cancer awareness.  Find a listing of them here.