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Prostate Cancer Discoveries Digest

Welcome to your monthly summary of the notable research studies and developments that help provide greater insight into prostate cancer causes, treatments, outcomes, and survivorship.

Prostate Cancer Discoveries Digest

Welcome to the April 2025 edition of ZERO's Prostate Cancer Discoveries Digest. The latest information on treatment, diagnostics, side effects, and more has been pulled from the headlines and delivered to your inbox.

Be sure to share this newsletter with your network to ensure that everyone receives the latest information on prostate cancer discoveries.

ZERO Prostate Cancer does not endorse any particular article or finding that may be featured.

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Treatment

FDA Expands Pluvicto's Metastatic Castration-Resistant Prostate Cancer Indication

The FDA has expanded the approval for Pluvicto to include adults with PSMA-positive mCRPC who have been treated with ARPI therapy and are considered appropriate to delay taxane-based chemotherapy.

» Full Article from the U.S. FDA

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Diagnostics

Microultrasonography-Guided vs. MRI-Guided Biopsy for Prostate Cancer Diagnosis

Results published in JAMA highlight results from a clinical trial in which researchers learned that microultrasonography might provide an alternative to MRI for image-guided prostate biopsy.

» Full Article from JAMA Network

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Side Effects

Novel Strategy Could Help Recover Function Following Prostate Cancer Surgery

A new strategy may improve function following surgery for prostate cancer, raising the prospect for significant quality of life improvements.

» Full Article from The ASCO Post

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Health Equity

Study Finds Geographic Disparities in MRI Use in Prostate Cancer

Racial disparities in MRI have decreased, but urban-rural and regional disparities persist, with rural areas less likely to utilize MRI, indicating a need for targeted interventions focused on geographical factors, among others.

» Full Article from Urology Times

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Screening

Males Who Skip Prostate Cancer Screenings Could Face 45% Higher Risk of Death

Although not yet published in a peer-reviewed journal, results from a new study found that 1 in 6 males skipped all of their prostate cancer screening appointments, leading to a 45% higher risk of death from the disease.

» Full Article from Healthline

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Diagnostics

PSMA PET for Prostate Cancer Diagnosis and Primary Staging Before Definitive Treatment

The diagnostic and staging accuracy of PSMA PET in prostate cancer was examined in a systematic review and meta-analysis to inform biopsy or lymph node dissection reliably.

» Full Article from the National Library of Medicine

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Treatment

Radical Prostatectomy Improves Cancer-Specific Survival in Oligometastatic Prostate Cancer

Surgery reduced the risk of cancer death among men with de novo oligometastatic prostate cancer receiving systemic therapy.

» Full Article from Renal+Urology News

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Side Effects

Exercise Can Lessen Fatigue in Prostate Cancer Patients Undergoing ADT

Results from a new study demonstrate that exercise can decrease fatigue, a common side effect, in patients with advanced prostate cancer undergoing ADT.

» Full Article from Clinical Oncology News

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Health Equity

Racial Variation in the Advanced Prostate Cancer Genome

Racial differences in the expression of certain prostate cancer driver gene pathways and DNA alterations highlight racial diversity's importance in future genomic profiling and clinical trial efforts.

» Full Article from Nature

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ZERO Prostate Cancer provides this informational roundup as a resource; it is not intended to replace medical professionals' or your healthcare team's recommendations. Consult your healthcare team if you have questions about your specific treatment plan.

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