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Popular drugs used for treating enlarged prostates associated with high-grade prostate cancer

Harvard University Health Shield

If a man has an enlarged prostate, there’s a good chance he’ll be treated with a type of drug called a 5-alpha reductase inhibitor (5-ARI). These drugs shrink the gland to improve urinary flow, and the approved forms used for treating enlarged prostates come in two varieties: Proscar (finasteride) and Avodart (dutasteride).

However, a side effect of 5-ARI inhibitor treatment is that it suppresses blood levels of prostate-specific antigen (PSA) by about 50%. Doctors measure PSA during prostate cancer screening, and if a man on 5-ARI therapy winds up with results that are artificially low, then he might be falsely reassured that he doesn’t need any additional prostate cancer testing.

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Source: Charlie Schmidt - Harvard Health Publications

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