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by Dr. Heather Cheng and Dr. Channing J. Paller   |   July 27, 2022

How Genetic Factors May Impact Prostate Cancer Risk And Treatment

We know that prostate cancer may be written in some men’s genes, but so are instructions for discovering new treatments and understanding family risk. If we want to better understand prostate cancer, we must better understand genes. That’s why the genetic information of prostate cancer patients is so important. This information is the next step in our collective fight against the disease

The PROMISE registry seeks to learn more about the role genes can play in improving outcomes and/or treatments for prostate cancer patients. This registry will help us understand how prostate cancer care can be tailored precisely based on a patient’s unique genetic profile. This means better information, testing, and choices. 

The PROMISE registry will enable us to examine how information about genetic profiles can:

  • Influence the susceptibility of men to prostate cancer
  • Impact the effectiveness of existing treatments
  • Improve guidance for different and/or new treatment options
  • Suggest precise areas to explore for new discoveries. 
How PROMISE works

PROMISE is completely free. Patients continue with their current provider and don’t even need to leave home to participate. Patients register online. They receive a simple home-based saliva sample DNA test kit. The kit will screen for one of 30 cancer risk genes. Patients will receive results and will be provided access to a licensed genetic counselor to help them understand the findings. Stringent measures are in place to ensure safety, privacy, and security.

Benefits of joining the PROMISE study

Prostate cancer patients who join PROMISE will:  

  • Receive free genetic testing and counseling; gain valuable information about genetic factors in cancer; and discover if they have a critical gene mutation that may impact their care plan. 
  • Receive the most current information about new research, clinical trial opportunities, and treatments approved by the FDA. 
  • Help family members understand their own risk of cancer and risk for future generations. 
  • Make an important contribution to advancing research and understanding of prostate cancer by providing essential genetic information and long-term outcomes that are not available anywhere else. 
Learn more

Visit ProstateCancerPromise.org, pcctcpromise@mskcc.org, or call 646-449-3363 to learn more. You can help win the fight against prostate cancer.