Racial disparities in prostate cancer are prevalent in the United States as African American men consistently experience a higher burden of prostate cancer incidence compared to European American men. While socioeconomic status, access to optimal care, and lifestyle factors can explain a part of these disparities, distinct molecular mechanisms and underlying biologic differences in African American men remain a major contributor to prostate cancer disparities. Advancements in research on the immune landscape of prostate cancer in European American men have lacked validation among their African American counterparts.